Is this product for human or veterinary use?

No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration. By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.

What does the Certificate of Analysis (COA) cover?

Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis. Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot at /lab-results and we'll email it within 1 business day.

How is the product shipped and stored in transit?

Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency. On receipt, store at -20°C in the sealed vial until reconstitution. Tracked shipping is included; we ship to all US states and most international destinations.

What does reconstitution look like in practice?

Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use the Peptide Calculator at /reconstitution-calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose. Once reconstituted, store at 2-8°C and use within 30 days. Protect the vial from light during storage and handling.

Can I return or exchange a vial?

Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we'll replace or refund. See the full returns policy at /returns for details.

Immune & Inflammatory Support

KPV 10mg

Name: KPV (10mg)
SKU: aero-52
Price: 39.99 USD
Availability: InStock

α-MSH (11-13)Lys-Pro-ValMelanocortin tripeptideMSH 11-13

KPV is the C-terminal tripeptide fragment of alpha-melanocyte-stimulating hormone (α-MSH), comprising the lysine-proline-valine residues responsible for much of α-MSH's reported anti-inflammatory signature. Published in vitro and rodent-model studies have characterised its uptake via the PepT1 transporter and its interaction with NF-κB and MAP kinase pathways in models of intestinal, dermal, and mucosal inflammation. For laboratory and research use only.

Dosage

10MG

$39.99

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Quantity

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Research focus

How KPV is studied

Summary of contexts in which this compound appears in the preclinical literature. See cited studies for primary sources.

Areas of research interest

Intestinal inflammation models
PepT1 transporter studies
NF-κB signalling research
Dermal and keratinocyte models
Mucosal barrier research
Melanocortin peptide biology
Antimicrobial peptide screens

Technical specifications

Compound & stability data

Compound Information

What is KPV (10mg)?

Tripeptide (α-MSH C-terminal fragment)

Type: Tripeptide (α-MSH C-terminal fragment)
CAS Number: 63631-40-3
Molecular Weight: 342.44 g/mol
Amino Acids: 3
Sequence: KPV
Formula: C16H30N4O4

View on PubChem ↗

Storage & Stability

Handling requirements

Lyophilized (powder)
-20°C • long-term stable in sealed lyophilized form
Reconstituted
2-8°C • use within 30 days of reconstitution
Light
Protect from light during storage and reconstitution
Room temperature
Short-term tolerant during shipping; minimise extended exposure above 25°C

Compound-specific notes

Aqueous KPV solutions show limited stability in published HPLC characterisation work; reconstituted material should be kept refrigerated, protected from light, and used within the validated window.

Dosing in the literature

Research dosing context

Observational summary of values reported in published research. Not a guide for human or animal use.

Reconstitution
KPV (342.44 g/mol) is highly water-soluble. Published in vitro work typically prepares stock solutions in phosphate-buffered saline or distilled water at 1–10 mM; a 10 mg vial dissolved in 1 mL bacteriostatic water yields approximately 29 mM stock. In vivo rodent studies used aqueous oral or intracolonic delivery vehicles.
Published protocols
In vitro keratinocyte and epithelial-cell studies used KPV at 10 nM – 10 µM (Elliott et al., J Invest Dermatol 2004; Mandrika et al., Peptides 2003). Murine IBD models administered 50–500 µg/mouse orally or intracolonically (Dalmasso et al., Gastroenterology 2008; Kannengiesser et al., IBD 2008). Nanoparticle-mediated oral delivery in colitis models was examined by Xiao et al. (Biomaterials 2017). No human RCT data are available; all published protocols are preclinical.
Half-life
KPV is a tripeptide subject to rapid peptidase degradation in plasma and gastrointestinal environments. No pharmacokinetic half-life measurement is reported in the cited papers. PepT1-mediated uptake characterised by Dalmasso et al. (Gastroenterology 2008) suggests intestinal absorption occurs intact at micromolar concentrations, but systemic half-life remains uncharacterised.
Post-reconstitution stability
Aqueous KPV solutions have shown limited stability in published HPLC characterisation work; the storage note on this file advises keeping reconstituted material refrigerated and protected from light, used within the validated window. No specific stability endpoint is reported in the cited literature.

In vitro concentrations from Elliott et al. (J Invest Dermatol 2004, PMID 15102092) and Mandrika et al. (Peptides 2003, PMID 12750433). In vivo dose ranges from Dalmasso et al. (Gastroenterology 2008, PMID 18061177) and Kannengiesser et al. (IBD 2008, PMID 18092346). Half-life not reported in cited references; general tripeptide PK literature cited as basis for instability note.

Sources & references

Peer-reviewed research

Gastroenterology

PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation

Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D

2008 · DOI: 10.1053/j.gastro.2007.10.026 · PMID: 18061177

Read on PubMed ↗

Inflammatory Bowel Diseases

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

Kannengiesser K, Maaser C, Heidemann J, et al.

2008 · DOI: 10.1002/ibd.20334 · PMID: 18092346

Read on PubMed ↗

Journal of Investigative Dermatology

alpha-Melanocyte-stimulating hormone, MSH 11-13 KPV and adrenocorticotropic hormone signalling in human keratinocyte cells

Elliott RJ, Szabo M, Wagner MJ, et al.

2004 · DOI: 10.1111/j.0022-202X.2004.22404.x · PMID: 15102092

Read on PubMed ↗

Annals of the New York Academy of Sciences

New insights into the functions of alpha-MSH and related peptides in the immune system

Luger TA, Scholzen TE, Brzoska T, et al.

2003 · DOI: 10.1111/j.1749-6632.2003.tb03172.x · PMID: 12851308

Read on PubMed ↗

Biomaterials

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

Xiao B, Xu Z, Viennois E, et al.

2017 · DOI: 10.1016/j.biomaterials.2017.01.022 · PMID: 28143741

Read on PubMed ↗

Peptides

Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides

Mandrika I, Muceniece R, Wikberg JE

2003 · DOI: 10.1016/s0196-9781(03)00115-7 · PMID: 12750433

Read on PubMed ↗

Journal of Leukocyte Biology

Antimicrobial effects of alpha-MSH peptides

Cutuli M, Cristiani S, Lipton JM, Catania A

1999 · DOI: 10.1002/jlb.66.6.1061 · PMID: 10670585

Read on PubMed ↗

British Journal of Pharmacology

Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore

Brzoska T, Böhm M, Lügering A, Loser K, Luger TA

2011 · DOI: 10.1111/j.1476-5381.2010.01205.x · PMID: 21222263

Read on PubMed ↗

Oncotarget

Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model

Viennois E, Pujada A, Sung J, et al.

2016 · DOI: 10.18632/oncotarget.10822 · PMID: 27458604

Read on PubMed ↗

9 peer-reviewed references listed. Citations verified against NCBI PubMed records. For research and educational reference only — does not constitute medical advice.

Researcher FAQ

Common questions

Is this product for human or veterinary use?
No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration.
By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.
What does the Certificate of Analysis (COA) cover?
Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis.
Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot and we’ll email it within 1 business day.
How is the product shipped and stored in transit?
Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency.
On receipt, store at −20°C in the sealed vial until reconstitution. See the handling matrix for full storage parameters. Tracked shipping is included; we ship to all US states and most international destinations.
What does reconstitution look like in practice?
Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use our Peptide Calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose.
Once reconstituted, store at 2–8°C and use within 30 days. Protect the vial from light during storage and handling.
Can I return or exchange a vial?
Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we’ll replace or refund.
See our full returns policy for details.

Don’t see your question? Contact our research team — we typically reply within one business day.

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⚠ Important research notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

KPV 10mg

α-MSH (11-13)Lys-Pro-ValMelanocortin tripeptideMSH 11-13