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Immune & Inflammatory Support
Semax is a synthetic heptapeptide developed in Russian neuropeptide research, structurally derived from a fragment of adrenocorticotropic hormone (ACTH 4-10) extended at the C-terminus with a Pro-Gly-Pro motif that confers marked proteolytic stability. Published rodent and in vitro work has characterised its interaction with brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, melanocortin-system signalling, and gene-expression patterns observed in cerebral ischaemia-reperfusion models. For laboratory and research use only.
Research focus
Summary of contexts in which this compound appears in the preclinical literature. See cited studies for primary sources.
Semax is a synthetic heptapeptide developed in Russian neuropeptide research, structurally derived from a fragment of adrenocorticotropic hormone (ACTH 4-10) extended at the C-terminus with a Pro-Gly-Pro motif that confers marked proteolytic stability. Published rodent and in vitro work has characterised its interaction with brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, melanocortin-system signalling, and gene-expression patterns observed in cerebral ischaemia-reperfusion models. For laboratory and research use only.
Areas of research interest
Technical specifications
Compound Information
Synthetic heptapeptide (ACTH 4-10 analogue)
Storage & Stability
Lyophilized (powder)
-20°C • long-term stable in sealed lyophilized form
Reconstituted
2-8°C • use within 30 days of reconstitution
Light
Protect from light during storage and reconstitution
Room temperature
Short-term tolerant during shipping; minimise extended exposure above 25°C
Compound-specific notes
The C-terminal Pro-Gly-Pro extension reported in the literature confers notable resistance to enzymatic degradation compared with the parent ACTH(4-10) fragment; standard cold-chain handling remains appropriate for reconstituted material.
Dosing in the literature
Observational summary of values reported in published research. Not a guide for human or animal use.
Reconstitution
Russian clinical literature describes Semax as an aqueous intranasal solution (typically 0.1% or 1% w/v, corresponding to ~1–10 mg/mL) rather than as a SC injectable preparation. Reconstitution for intranasal research use would typically target these concentrations in sterile saline or water.
Published protocols
Published protocols in the cited Russian neuropeptide literature are predominantly intranasal. Dolotov et al. (J Neurochem, 2006; Brain Research, 2006) and Agapova et al. (Neuroscience Letters, 2007) administered Semax intranasally to rats. Medvedeva et al. (BMC Genomics, 2014) and Dmitrieva et al. (Cell Mol Neurobiol, 2010) used intranasal delivery in cerebral ischaemia models. No SC injection protocol is established in the cited literature.
Half-life
No precise plasma half-life is reported in the cited publications. The C-terminal Pro-Gly-Pro extension confers documented proteolytic resistance relative to the ACTH(4-10) parent fragment (storage specification note); functional duration in rodent behavioural and gene-expression studies extends over hours, but formal PK characterisation is not reported in the cited Dolotov, Agapova, Shadrina, or Dmitrieva papers.
Post-reconstitution stability
~28 days at 2–8 °C in BAC-water solution under standard peptide handling. The Pro-Gly-Pro extension improves enzymatic stability in solution relative to parent ACTH fragments, as described in the cited literature.
Reconstitution framing based on concentrations reported in Russian clinical and preclinical literature (Dolotov et al. 2006; Medvedeva et al. 2014). Route of administration is predominantly intranasal per all cited publications — no SC injection protocol is cited. PK half-life is not characterised in the cited studies.
Sources & references
Journal of Neurochemistry
Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain
Dolotov OV, Karpenko EA, Seredenina TS, et al.
2006 · DOI: 10.1111/j.1471-4159.2006.03658.x · PMID: 16635254
Read on PubMed ↗Brain Research
Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus
Dolotov OV, Karpenko EA, Inozemtseva LS, et al.
2006 · DOI: 10.1016/j.brainres.2006.07.108 · PMID: 16996037
Read on PubMed ↗Neuroscience Letters
Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10
Agapova TY, Agniullin YV, Shadrina MI, et al.
2007 · DOI: 10.1016/j.neulet.2007.02.042 · PMID: 17353092
Read on PubMed ↗Journal of Molecular Neuroscience
Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action
Shadrina M, Kolomin T, Agapova T, et al.
2010 · DOI: 10.1007/s12031-009-9270-z · PMID: 19662538
Read on PubMed ↗Cellular and Molecular Neurobiology
Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia
Dmitrieva VG, Povarova OV, Skvortsova VI, et al.
2010 · DOI: 10.1007/s10571-009-9432-0 · PMID: 19633950
Read on PubMed ↗BMC Genomics
The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis
Medvedeva EV, Dmitrieva VG, Povarova OV, et al.
2014 · DOI: 10.1186/1471-2164-15-228 · PMID: 24661604
Read on PubMed ↗Doklady Biological Sciences
Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats
Yatsenko KA, Glazova NY, Inozemtseva LS, et al.
2013 · DOI: 10.1134/S0012496613060161 · PMID: 24385169
Read on PubMed ↗International Journal of Molecular Sciences
Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion
Sudarkina OY, Filippenkov IB, Stavchansky VV, et al.
2021 · DOI: 10.3390/ijms22126179 · PMID: 34201112
Read on PubMed ↗Journal of Inorganic Biochemistry
Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties
Magrì A, Tabbì G, Giuffrida A, et al.
2016 · DOI: 10.1016/j.jinorgbio.2016.08.013 · PMID: 27586814
Read on PubMed ↗9 peer-reviewed references listed. Citations verified against NCBI PubMed records. For research and educational reference only — does not constitute medical advice.
Researcher FAQ
No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration.
By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.
Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis.
Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot and we’ll email it within 1 business day.
Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency.
On receipt, store at −20°C in the sealed vial until reconstitution. See the handling matrix for full storage parameters. Tracked shipping is included; we ship to all US states and most international destinations.
Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use our Peptide Calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose.
Once reconstituted, store at 2–8°C and use within 30 days. Protect the vial from light during storage and handling.
Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we’ll replace or refund.
See our full returns policy for details.
Don’t see your question? Contact our research team — we typically reply within one business day.
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⚠ Important research notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
