Frontiers in Pharmacology
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
Seiwerth S, Milavic M, Vukojevic J, et al.
2021 · DOI: 10.3389/fphar.2021.627533 · PMID: 34267654
Read on PubMed ↗
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Repair & Recovery
BPC-157 is a synthetic pentadecapeptide derived from a protective protein fragment originally isolated from human gastric juice. In vitro and animal-model studies have examined its interaction with angiogenic, nitric-oxide, and growth-factor signalling pathways relevant to soft-tissue research. For laboratory and research use only.
Research focus
Summary of contexts in which this compound appears in the preclinical literature. See cited studies for primary sources.
BPC-157 is a synthetic pentadecapeptide derived from a protective protein fragment originally isolated from human gastric juice. In vitro and animal-model studies have examined its interaction with angiogenic, nitric-oxide, and growth-factor signalling pathways relevant to soft-tissue research. For laboratory and research use only.
Areas of research interest
Technical specifications
Compound Information
Synthetic pentadecapeptide
Storage & Stability
Lyophilized (powder)
-20°C • long-term stable in sealed lyophilized form
Reconstituted
2-8°C • use within 30 days of reconstitution
Light
Protect from light during storage and reconstitution
Room temperature
Short-term tolerant during shipping; minimise extended exposure above 25°C
Compound-specific notes
Demonstrates notable stability in gastric-juice conditions in published preclinical work, distinguishing it from many peptides degraded by acidic environments.
Dosing in the literature
Observational summary of values reported in published research. Not a guide for human or animal use.
Reconstitution
Typically 2–3 mL bacteriostatic water per 10 mg vial, yielding ~3.3–5 mg/mL working concentration in research preparations.
Published protocols
Animal-model studies commonly report 10–500 µg/kg/day in rat models, administered intraperitoneally or subcutaneously over the experimental window.
Half-life
~30 min plasma half-life reported in rat models (subcutaneous administration).
Post-reconstitution stability
~28 days at 2–8 °C in BAC-water solution; degradation reported above 25 °C.
Values summarised from cited preclinical studies (see references below). No standardised human research protocol exists; clinical use is not established.
Sources & references
Frontiers in Pharmacology
Stable Gastric Pentadecapeptide BPC 157 and Wound Healing
Seiwerth S, Milavic M, Vukojevic J, et al.
2021 · DOI: 10.3389/fphar.2021.627533 · PMID: 34267654
Read on PubMed ↗Cell and Tissue Research
Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing
Gwyer D, Wragg NM, Wilson SL
2019 · DOI: 10.1007/s00441-019-03016-8 · PMID: 30915550
Read on PubMed ↗Journal of Applied Physiology
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
Chang CH, Tsai WC, Lin MS, et al.
2011 · DOI: 10.1152/japplphysiol.00945.2010 · PMID: 21030672
Read on PubMed ↗Neural Regeneration Research
Pentadecapeptide BPC 157 and the central nervous system
Vukojevic J, Milavić M, Perović D, et al.
2022 · DOI: 10.4103/1673-5374.320969 · PMID: 34380875
Read on PubMed ↗Biomedicines
Stable Gastric Pentadecapeptide BPC 157 and Striated, Smooth, and Heart Muscle
Staresinic M, Japjec M, Vranes H, et al.
2022 · DOI: 10.3390/biomedicines10123221 · PMID: 36551977
Read on PubMed ↗Journal of Orthopaedic Research
Achilles detachment in rat and stable gastric pentadecapeptide BPC 157
Krivic A, Anic T, Seiwerth S, et al.
2006 · DOI: 10.1002/jor.20096 · PMID: 16583442
Read on PubMed ↗Current Pharmaceutical Design
Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy
Sikiric P, Drmic D, Sever M, et al.
2020 · DOI: 10.2174/1381612826666200424180139 · PMID: 32329684
Read on PubMed ↗Brain and Behavior
The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries
Vukojević J, Vrdoljak B, Malekinušić D, et al.
2020 · DOI: 10.1002/brb3.1726 · PMID: 32558293
Read on PubMed ↗8 peer-reviewed references listed. Citations verified against NCBI PubMed records. For research and educational reference only — does not constitute medical advice.
Researcher FAQ
No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration.
By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.
Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis.
Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot and we’ll email it within 1 business day.
Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency.
On receipt, store at −20°C in the sealed vial until reconstitution. See the handling matrix for full storage parameters. Tracked shipping is included; we ship to all US states and most international destinations.
Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use our Peptide Calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose.
Once reconstituted, store at 2–8°C and use within 30 days. Protect the vial from light during storage and handling.
Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we’ll replace or refund.
See our full returns policy for details.
Don’t see your question? Contact our research team — we typically reply within one business day.
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⚠ Important research notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.