Is this product for human or veterinary use?

No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration. By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.

What does the Certificate of Analysis (COA) cover?

Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis. Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot at /lab-results and we'll email it within 1 business day.

How is the product shipped and stored in transit?

Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency. On receipt, store at -20°C in the sealed vial until reconstitution. Tracked shipping is included; we ship to all US states and most international destinations.

What does reconstitution look like in practice?

Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use the Peptide Calculator at /reconstitution-calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose. Once reconstituted, store at 2-8°C and use within 30 days. Protect the vial from light during storage and handling.

Can I return or exchange a vial?

Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we'll replace or refund. See the full returns policy at /returns for details.

Skin, Hair & Cosmetic

GHK-CU 100mg

Name: GHK-CU (100mg)
SKU: aero-40
Price: 44.99 USD
Availability: InStock

Copper Tripeptide-1Glycyl-L-histidyl-L-lysine-copperCu-GHKPC-1031

GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine complexed with Cu(II)) whose endogenous serum levels decline measurably with age. Published preclinical and in vitro research has examined its interaction with extracellular matrix remodelling, broad gene-expression modulation, antioxidant and anti-inflammatory pathways, and copper-coordination chemistry in cultured fibroblasts and animal wound models. The compound has been a subject of biochemical investigation since its isolation from human plasma in the 1970s. For laboratory and research use only.

Dosage

100MG

$44.99

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Quantity

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Research focus

How GHK-CU is studied

Summary of contexts in which this compound appears in the preclinical literature. See cited studies for primary sources.

Areas of research interest

Extracellular matrix remodelling
Fibroblast collagen synthesis
Antioxidant and lipid-peroxidation models
Gene-expression modulation
Copper coordination chemistry
Dermal wound-healing models
Hair follicle research
Inflammatory signalling pathways

Technical specifications

Compound & stability data

Compound Information

What is GHK-CU (100mg)?

Copper-binding tripeptide complex

Type: Copper-binding tripeptide complex
CAS Number: 49557-75-7
Molecular Weight: 402.92 g/mol
Amino Acids: 3
Sequence: GHK
Formula: C14H24CuN6O4

View on PubChem ↗

Storage & Stability

Handling requirements

Lyophilized (powder)
-20°C • long-term stable in sealed lyophilized form
Reconstituted
2-8°C • use within 30 days of reconstitution
Light
Protect from light during storage and reconstitution
Room temperature
Short-term tolerant during shipping; minimise extended exposure above 25°C

Compound-specific notes

Copper-bound preparation typically presents as a blue lyophilized solid. Avoid contact with strong reducing agents; protect from light to limit photochemical decomposition of the copper coordination complex.

Dosing in the literature

Research dosing context

Observational summary of values reported in published research. Not a guide for human or animal use.

Reconstitution
Typically 2–3 mL bacteriostatic water per 100 mg vial, yielding ~33–50 mg/mL stock. Topical research formulations are commonly diluted to 0.05–0.2% (w/v).
Published protocols
In-vitro fibroblast and gene-expression studies commonly use 1–100 nM. Topical cosmetic-research formulations report 0.05–0.2% concentrations. Parenteral protocols are not well-standardised.
Half-life
Plasma half-life ~30 min in vivo; reduced to copper-free GHK in serum. Topical absorption studied separately.
Post-reconstitution stability
~28 days at 2–8 °C, protected from light (copper complex is photosensitive).

Values from cited Pickart fibroblast/dermal research and Pyo follicle work. Protocols vary by route — no single standardised regimen.

Sources & references

Peer-reviewed research

BioMed Research International

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

Pickart L, Vasquez-Soltero JM, Margolina A

2015 · DOI: 10.1155/2015/648108 · PMID: 26236730

Read on PubMed ↗

Oxidative Medicine and Cellular Longevity

The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging

Pickart L, Vasquez-Soltero JM, Margolina A

2012 · DOI: 10.1155/2012/324832 · PMID: 22666519

Read on PubMed ↗

Journal of Biomaterials Science, Polymer Edition

The human tri-peptide GHK and tissue remodeling

Pickart L

2008 · DOI: 10.1163/156856208784909435 · PMID: 18644225

Read on PubMed ↗

Brain Sciences

The Effect of the Human Peptide GHK on Gene Expression Relevant to Nervous System Function and Cognitive Decline

Pickart L, Vasquez-Soltero JM, Margolina A

2017 · DOI: 10.3390/brainsci7020020 · PMID: 28212278

Read on PubMed ↗

FEBS Letters

Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

Maquart FX, Pickart L, Laurent M, et al.

1988 · DOI: 10.1016/0014-5793(88)80509-x · PMID: 3169264

Read on PubMed ↗

Advances in Experimental Medicine and Biology

Effects of glycyl-histidyl-lysyl chelated Cu(II) on ferritin dependent lipid peroxidation

Miller DM, DeSilva D, Pickart L

1990 · DOI: 10.1007/978-1-4684-5730-8_11 · PMID: 2244543

Read on PubMed ↗

Cosmetics

GHK and DNA: Resetting the Human Genome to Health

Pickart L, Vasquez-Soltero JM, Margolina A

2014 · DOI: 10.1155/2014/151479 · PMID: 25210707

Read on PubMed ↗

FASEB Journal

Tripeptide-copper complex GHK-Cu(2+) transiently activates the inflammatory response in Jurkat T-cells and B-cell lymphoma cells

Gruchlik A, Jurzak M, Chodurek E, Dzierżewicz Z

2010 · DOI: 10.1096/fasebj.24.1_supplement.lb87 · PMID: 20639517

Read on PubMed ↗

Experimental Dermatology

Effect of the tripeptide-copper complex L-alanyl-L-histidyl-L-lysine-Cu2+ on hair growth in C57BL/6 mice

Pyo HK, Yoo HG, Won CH, et al.

2007 · DOI: 10.1111/j.1600-0625.2007.00576.x · PMID: 17542980

Read on PubMed ↗

Annals of the New York Academy of Sciences

Iamin: a human growth factor with multiple wound-healing properties

Pickart L, Lovejoy S

1989 · DOI: 10.1111/j.1749-6632.1989.tb55807.x · PMID: 2774355

Read on PubMed ↗

10 peer-reviewed references listed. Citations verified against NCBI PubMed records. For research and educational reference only — does not constitute medical advice.

Researcher FAQ

Common questions

Is this product for human or veterinary use?
No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration.
By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.
What does the Certificate of Analysis (COA) cover?
Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis.
Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot and we’ll email it within 1 business day.
How is the product shipped and stored in transit?
Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency.
On receipt, store at −20°C in the sealed vial until reconstitution. See the handling matrix for full storage parameters. Tracked shipping is included; we ship to all US states and most international destinations.
What does reconstitution look like in practice?
Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use our Peptide Calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose.
Once reconstituted, store at 2–8°C and use within 30 days. Protect the vial from light during storage and handling.
Can I return or exchange a vial?
Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we’ll replace or refund.
See our full returns policy for details.

Don’t see your question? Contact our research team — we typically reply within one business day.

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⚠ Important research notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

GHK-CU 100mg

Copper Tripeptide-1Glycyl-L-histidyl-L-lysine-copperCu-GHKPC-1031