Is this product for human or veterinary use?

No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration. By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.

What does the Certificate of Analysis (COA) cover?

Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis. Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot at /lab-results and we'll email it within 1 business day.

How is the product shipped and stored in transit?

Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency. On receipt, store at -20°C in the sealed vial until reconstitution. Tracked shipping is included; we ship to all US states and most international destinations.

What does reconstitution look like in practice?

Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use the Peptide Calculator at /reconstitution-calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose. Once reconstituted, store at 2-8°C and use within 30 days. Protect the vial from light during storage and handling.

Can I return or exchange a vial?

Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we'll replace or refund. See the full returns policy at /returns for details.

Cellular Health & Longevity

NAD+ 100mg

Name: NAD+ (100mg)
SKU: aero-46
Price: 59.99 USD
Availability: InStock

Nicotinamide Adenine Dinucleotideβ-NAD+β-NADCoenzyme I

NAD+ (nicotinamide adenine dinucleotide) is an endogenous pyridine-nucleotide coenzyme central to cellular redox biology and a required substrate for the sirtuin, PARP, and CD38 enzyme families. A substantial research literature has characterised its role in mitochondrial bioenergetics, DNA-damage signalling, and age-associated metabolic pathways, with preclinical models examining how cellular NAD+ pools change across tissue and lifespan. For laboratory and research use only.

Dosage

100MG

$59.99

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Quantity

Ships quickly after your order is placed

Damage protection

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Research focus

How NAD+ is studied

Summary of contexts in which this compound appears in the preclinical literature. See cited studies for primary sources.

Areas of research interest

Sirtuin pathway research
Mitochondrial metabolism
Cellular energy and redox models
Aging biology
PARP and DNA-damage signalling
CD38 enzymology
NAD+ precursor pharmacology

Technical specifications

Compound & stability data

Compound Information

What is NAD+ (100mg)?

Pyridine nucleotide coenzyme

Type: Pyridine nucleotide coenzyme
CAS Number: 53-84-9
Molecular Weight: 663.43 g/mol
Amino Acids: —
Sequence: —
Formula: C21H27N7O14P2

View on PubChem ↗

Storage & Stability

Handling requirements

Lyophilized (powder)
-20°C • long-term stable in sealed lyophilized form
Reconstituted
2-8°C • use within 14 days of reconstitution (shorter than typical peptide window)
Light
Photosensitive — protect from light during storage and reconstitution; the nicotinamide moiety is reported to degrade on UV exposure
Room temperature
Short-term tolerant during shipping; minimise extended exposure above 25°C

Compound-specific notes

Distinct from peptide compounds: NAD+ is a small-molecule dinucleotide that undergoes hydrolysis in aqueous solution more rapidly than most peptides, and is reported to be hygroscopic. Reconstitute close to time of use and minimise freeze-thaw cycles.

Dosing in the literature

Research dosing context

Observational summary of values reported in published research. Not a guide for human or animal use.

Reconstitution
Typically 3–5 mL sterile or bacteriostatic water per 100 mg vial, yielding a 20–33 mg/mL working concentration. Aqueous solubility is high; vortex gently until fully dissolved.
Published protocols
No standardised parenteral research protocol exists for exogenous NAD+ administration. Rajman et al. (Cell Metabolism, 2018) reviewed preclinical NMN/NR supplementation studies; Guarente, Sinclair & Kroemer (Cell Metabolism, 2024) noted that human trials have used oral NMN and NR precursors rather than direct NAD+ parenteral dosing. Published IV NAD+ infusion work is limited to small clinical reports and addiction-medicine contexts not represented in the cited literature.
Half-life
NAD+ half-life in circulating blood is short (minutes to low hours) due to rapid tissue uptake and enzymatic cycling; precise parenteral pharmacokinetic parameters are not established in the cited literature. Verdin (Science, 2015) and Gomes et al. (Cell, 2013) describe tissue NAD+ dynamics in the context of aging and metabolic stress rather than exogenous infusion kinetics.
Post-reconstitution stability
~14 days at 2–8 °C as noted in storage specification; shorter than typical peptides. NAD+ undergoes hydrolysis in aqueous solution and is hygroscopic — reconstitute close to time of use.

Reconstitution and stability values from general NAD+ biochemistry; no SKU-specific stability studies cited. Parenteral PK values are absent from the cited Verdin, Rajman, Zhang, Yoshino, Cantó, Gomes, Chini, and Guarente publications, which focus on cellular and preclinical contexts rather than exogenous infusion pharmacokinetics.

Sources & references

Peer-reviewed research

Science

NAD+ in aging, metabolism, and neurodegeneration

Verdin E

2015 · DOI: 10.1126/science.aac4854 · PMID: 26785480

Read on PubMed ↗

Cell Metabolism

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Rajman L, Chwalek K, Sinclair DA

2018 · DOI: 10.1016/j.cmet.2018.02.011 · PMID: 29514064

Read on PubMed ↗

Science

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang H, Ryu D, Wu Y, et al.

2016 · DOI: 10.1126/science.aaf2693 · PMID: 27127236

Read on PubMed ↗

Cell Metabolism

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Yoshino J, Baur JA, Imai S

2018 · DOI: 10.1016/j.cmet.2017.11.002 · PMID: 29249689

Read on PubMed ↗

Cell Metabolism

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

Cantó C, Houtkooper RH, Pirinen E, et al.

2012 · DOI: 10.1016/j.cmet.2012.04.022 · PMID: 22682224

Read on PubMed ↗

Cell

Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Gomes AP, Price NL, Ling AJY, et al.

2013 · DOI: 10.1016/j.cell.2013.11.037 · PMID: 24360282

Read on PubMed ↗

Nature Metabolism

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Chini CCS, Peclat TR, Warner GM, et al.

2020 · DOI: 10.1038/s42255-020-00298-z · PMID: 33199925

Read on PubMed ↗

Cell Metabolism

Human trials exploring anti-aging medicines

Guarente L, Sinclair DA, Kroemer G

2024 · DOI: 10.1016/j.cmet.2023.12.007 · PMID: 38181790

Read on PubMed ↗

8 peer-reviewed references listed. Citations verified against NCBI PubMed records. For research and educational reference only — does not constitute medical advice.

Researcher FAQ

Common questions

Is this product for human or veterinary use?
No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration.
By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.
What does the Certificate of Analysis (COA) cover?
Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis.
Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot and we’ll email it within 1 business day.
How is the product shipped and stored in transit?
Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency.
On receipt, store at −20°C in the sealed vial until reconstitution. See the handling matrix for full storage parameters. Tracked shipping is included; we ship to all US states and most international destinations.
What does reconstitution look like in practice?
Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use our Peptide Calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose.
Once reconstituted, store at 2–8°C and use within 30 days. Protect the vial from light during storage and handling.
Can I return or exchange a vial?
Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we’ll replace or refund.
See our full returns policy for details.

Don’t see your question? Contact our research team — we typically reply within one business day.

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⚠ Important research notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

NAD+ 100mg

Nicotinamide Adenine Dinucleotideβ-NAD+β-NADCoenzyme I