Is this product for human or veterinary use?

No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration. By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.

What does the Certificate of Analysis (COA) cover?

Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis. Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot at /lab-results and we'll email it within 1 business day.

How is the product shipped and stored in transit?

Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency. On receipt, store at -20°C in the sealed vial until reconstitution. Tracked shipping is included; we ship to all US states and most international destinations.

What does reconstitution look like in practice?

Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use the Peptide Calculator at /reconstitution-calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose. Once reconstituted, store at 2-8°C and use within 30 days. Protect the vial from light during storage and handling.

Can I return or exchange a vial?

Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we'll replace or refund. See the full returns policy at /returns for details.

Metabolics & Appetite

GLP3 – Reta (10-20mg)

Name: GLP3 – Reta (10-20mg)
SKU: aero-23
Availability: InStock

LY3437943Triple-agonist GGGGIP/GLP-1/Glucagon RATriple incretin receptor agonist

Retatrutide is an investigational 39-amino-acid, fatty-acid-acylated triple agonist engineered to engage the GIP, GLP-1, and glucagon receptors from a single peptide backbone. Phase 2 trial cohorts and supporting preclinical work have characterised its receptor pharmacology, gastric-emptying effects, and observed changes in body composition and hepatic-fat endpoints in obesity and MASLD research populations. Reported phase 1b and phase 2 data describe dose-ranging pharmacokinetic and pharmacodynamic profiles, while structural biology studies have begun to map its binding mode across the three class B GPCRs. Discussed here strictly as an investigational research compound; AeroPeptides supplies retatrutide for in vitro and non-clinical laboratory study only. For laboratory and research use only.

Dosage

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Research focus

How GLP3 – Reta (10-20mg) is studied

Summary of contexts in which this compound appears in the preclinical literature. See cited studies for primary sources.

Areas of research interest

Triple incretin receptor pharmacology
GIP / GLP-1 / glucagon signalling
Obesity research cohorts (phase 2)
MASLD / hepatic-fat endpoints
Type 2 diabetes phase 1b/2 dose-ranging
Gastric-emptying and PK/PD models
Structural biology of class B GPCRs
Body-composition and energy-expenditure research

Technical specifications

Compound & stability data

Compound Information

What is GLP3 – Reta (10-20mg)?

Triple receptor agonist GIP/GLP-1/Glucagon (39 amino acids)

Type: Triple receptor agonist GIP/GLP-1/Glucagon (39 amino acids)
CAS Number: 2381089-83-2
Molecular Weight: 4731.45 g/mol
Amino Acids: 39
Sequence: YXQGTFTSDYSKYLDERAAXDFVQWLLAGGPSSGAPPPS
Formula: C221H343N47O67

View on PubChem ↗

Storage & Stability

Handling requirements

Lyophilized (powder)
-20°C • long-term stable in sealed lyophilized form
Reconstituted
2-8°C • use within 30 days of reconstitution
Light
Protect from light during storage and reconstitution
Room temperature
Short-term tolerant during shipping; minimise extended exposure above 25°C

Dosing in the literature

Research dosing context

Observational summary of values reported in published research. Not a guide for human or animal use.

Reconstitution
Typically 1–2 mL bacteriostatic water per 10 mg vial, yielding ~5–10 mg/mL working concentration in research preparations.
Published protocols
Phase 2 trials (Jastreboff 2023, NEJM) evaluated weekly subcutaneous doses of 1, 4, 8, and 12 mg in obesity research cohorts. Phase 1b dose-escalation went up to 12 mg single SC.
Half-life
~6 days in human pharmacokinetic studies, supporting once-weekly dosing in trial protocols.
Post-reconstitution stability
~28 days at 2–8 °C in BAC-water solution.

Values from cited NEJM 2023 phase 2 trial and Urva 2022 phase 1b PK study. Clinical-trial dose ranges only — no general-use protocols established.

Sources & references

Peer-reviewed research

New England Journal of Medicine

Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial

Jastreboff AM, Kaplan LM, Frías JP, et al.

2023 · DOI: 10.1056/NEJMoa2301972 · PMID: 37366315

Read on PubMed ↗

Nature Medicine

Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial

Sanyal AJ, Kaplan LM, Frias JP, et al.

2024 · DOI: 10.1038/s41591-024-03018-2 · PMID: 38858523

Read on PubMed ↗

Cell Metabolism

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept

Coskun T, Urva S, Roell WC, et al.

2022 · DOI: 10.1016/j.cmet.2022.07.013 · PMID: 35985340

Read on PubMed ↗

The Lancet

LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial

Urva S, Coskun T, Loh MT, et al.

2022 · DOI: 10.1016/S0140-6736(22)02033-5 · PMID: 36354040

Read on PubMed ↗

The Lancet

Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA

Rosenstock J, Frias J, Jastreboff AM, et al.

2023 · DOI: 10.1016/S0140-6736(23)01053-X · PMID: 37385280

Read on PubMed ↗

Diabetes, Obesity and Metabolism

The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying

Urva S, Quinlan T, Landry J, et al.

2023 · DOI: 10.1111/dom.15167 · PMID: 37311727

Read on PubMed ↗

Cell Discovery

Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

Li W, Zhou Q, Cong Z, et al.

2024 · DOI: 10.1038/s41421-024-00702-y · PMID: 39019866

Read on PubMed ↗

European Journal of Clinical Pharmacology

A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity

Kaur M, Misra S

2024 · DOI: 10.1007/s00228-024-03646-0 · PMID: 38367045

Read on PubMed ↗

Cardiology in Review

The First Triple Agonist for Antiobesity: Retatrutide

Tetelbaum L, Mullally JA, Frishman WH

2024 · DOI: 10.1097/CRD.0000000000000793 · PMID: 39724554

Read on PubMed ↗

NPJ Metabolic Health and Disease

Incretin triple agonist retatrutide alleviates obesity-associated cancer progression

Marathe SJ, Grey EW, Bohm MS, et al.

2025 · DOI: 10.1038/s44324-025-00054-5 · PMID: 40094000

Read on PubMed ↗

10 peer-reviewed references listed. Citations verified against NCBI PubMed records. For research and educational reference only — does not constitute medical advice.

Researcher FAQ

Common questions

Is this product for human or veterinary use?
No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration.
By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.
What does the Certificate of Analysis (COA) cover?
Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis.
Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot and we’ll email it within 1 business day.
How is the product shipped and stored in transit?
Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency.
On receipt, store at −20°C in the sealed vial until reconstitution. See the handling matrix for full storage parameters. Tracked shipping is included; we ship to all US states and most international destinations.
What does reconstitution look like in practice?
Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use our Peptide Calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose.
Once reconstituted, store at 2–8°C and use within 30 days. Protect the vial from light during storage and handling.
Can I return or exchange a vial?
Because peptides are temperature-sensitive research materials, we cannot accept returns of opened or unsealed vials. If a shipment arrives damaged or the seal is broken on arrival, contact us within 7 days and we’ll replace or refund.
See our full returns policy for details.

Don’t see your question? Contact our research team — we typically reply within one business day.

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⚠ Important research notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

GLP3 – Reta (10-20mg)

LY3437943Triple-agonist GGGGIP/GLP-1/Glucagon RATriple incretin receptor agonist