European Journal of Endocrinology
Ipamorelin, the first selective growth hormone secretagogue
Raun K, Hansen BS, Johansen NL, et al.
1998 · DOI: 10.1530/eje.0.1390552 · PMID: 9849822
Read on PubMed ↗
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Growth Hormone Support
A blended preparation pairing CJC-1295 without DAC (also known as Modified GRF(1-29), a 29-amino-acid growth-hormone-releasing-hormone analogue) with ipamorelin, a pentapeptide growth-hormone secretagogue that acts as a selective agonist at the ghrelin / GHS-R1a receptor. The two compounds engage distinct, complementary nodes of the somatotropic axis: GHRH-receptor stimulation at the anterior pituitary and ghrelin-receptor activation at both pituitary and hypothalamic sites. Classical work by Bowers and colleagues established that GHRH and GHRP-class secretagogues produce additive-to-synergistic effects on GH release in vivo, and subsequent preclinical work has extended this observation to long-acting GHRH analogues co-administered with selective ghrelin mimetics. Ipamorelin is distinguished within its class by selectivity: published characterisation reports GH release without meaningful elevation of ACTH, cortisol, prolactin, FSH, LH or TSH. Supplied as a research-grade blended preparation for in vitro and animal-model laboratory study of dual-pathway secretagogue pharmacology, receptor cross-talk, and pulsatility. For laboratory and research use only.
Research focus
Summary of contexts in which this compound appears in the preclinical literature. See cited studies for primary sources.
A blended preparation pairing CJC-1295 without DAC (also known as Modified GRF(1-29), a 29-amino-acid growth-hormone-releasing-hormone analogue) with ipamorelin, a pentapeptide growth-hormone secretagogue that acts as a selective agonist at the ghrelin / GHS-R1a receptor. The two compounds engage distinct, complementary nodes of the somatotropic axis: GHRH-receptor stimulation at the anterior pituitary and ghrelin-receptor activation at both pituitary and hypothalamic sites. Classical work by Bowers and colleagues established that GHRH and GHRP-class secretagogues produce additive-to-synergistic effects on GH release in vivo, and subsequent preclinical work has extended this observation to long-acting GHRH analogues co-administered with selective ghrelin mimetics. Ipamorelin is distinguished within its class by selectivity: published characterisation reports GH release without meaningful elevation of ACTH, cortisol, prolactin, FSH, LH or TSH. Supplied as a research-grade blended preparation for in vitro and animal-model laboratory study of dual-pathway secretagogue pharmacology, receptor cross-talk, and pulsatility. For laboratory and research use only.
Areas of research interest
Technical specifications
Compound Information
Blended research peptides (two constituents)
CJC-1295 (no DAC) / ModGRF(1-29)
Ipamorelin
Storage & Stability
Lyophilized (powder)
-20°C • long-term stable in sealed lyophilized form
Reconstituted
2-8°C • use within 30 days of reconstitution
Light
Protect from light during storage and reconstitution
Room temperature
Short-term tolerant during shipping; minimise extended exposure above 25°C
Dosing in the literature
Observational summary of values reported in published research. Not a guide for human or animal use.
Reconstitution
Blended preparations are typically reconstituted in 1 mL bacteriostatic water per 5 mg vial, yielding a combined working concentration of ~5 mg/mL for each constituent in research preparations.
Published protocols
Preclinical studies of combined GHRH / GHRP administration (Fintini et al. 2006, Bowers et al. 1990) used SC injection routes in rodent models. Ipamorelin PK characterisation (Johansen et al. 1998) reported SC and IV administration in animal cohorts; no blended human clinical trial protocols have been published.
Half-life
~30 minutes for CJC-1295 without DAC (short-acting, no albumin binding); ~2 hours for ipamorelin in preclinical PK studies (Johansen et al. 1998).
Post-reconstitution stability
~28 days at 2–8 °C in BAC-water solution.
Half-life values from Johansen et al. 1998 (Xenobiotica, PMID 9879640) for ipamorelin and from published GHRH(1-29) PK literature. Reconstitution range based on general blended-peptide research conventions; no dedicated blended-preparation PK trial is cited on this file.
Sources & references
European Journal of Endocrinology
Ipamorelin, the first selective growth hormone secretagogue
Raun K, Hansen BS, Johansen NL, et al.
1998 · DOI: 10.1530/eje.0.1390552 · PMID: 9849822
Read on PubMed ↗Xenobiotica
Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption
Johansen PB, Hansen KT, Andersen JV, et al.
1998 · DOI: 10.1080/004982598238976 · PMID: 9879640
Read on PubMed ↗Growth Hormone & IGF Research
Growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced growth retardation
Andersen NB, Malmlöf K, Johansen PB, et al.
2001 · DOI: 10.1054/ghir.2001.0239 · PMID: 11735244
Read on PubMed ↗Histology and Histopathology
Influence of chronic treatment with growth hormone secretagogue ipamorelin in the histomorphometry of male rat hypophysis
Jiménez-Reina L, Cañete R, de la Torre MJ, et al.
2002 · DOI: 10.14670/HH-17.707 · PMID: 12168778
Read on PubMed ↗Endocrinology
Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog
Jetté L, Léger R, Thibaudeau K, et al.
2005 · DOI: 10.1210/en.2004-1286 · PMID: 15817669
Read on PubMed ↗Neuroendocrinology
Effects of combined long-term treatment with a growth hormone-releasing hormone analogue and a growth hormone secretagogue in the growth hormone-releasing hormone knock out mouse
Fintini D, Alba M, Schally AV, et al.
2005 · DOI: 10.1159/000092520 · PMID: 16601359
Read on PubMed ↗American Journal of Physiology - Endocrinology and Metabolism
Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse
Alba M, Fintini D, Sagazio A, et al.
2006 · DOI: 10.1152/ajpendo.00201.2006 · PMID: 16822960
Read on PubMed ↗Journal of Clinical Endocrinology & Metabolism
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults
Teichman SL, Neale A, Lawrence B, et al.
2006 · DOI: 10.1210/jc.2005-1536 · PMID: 16352683
Read on PubMed ↗Journal of Clinical Endocrinology & Metabolism
Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone
Bowers CY, Reynolds GA, Durham D, et al.
1990 · DOI: 10.1210/jcem-70-4-975 · PMID: 2108187
Read on PubMed ↗Journal of Pharmacology and Experimental Therapeutics
Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus
Venkova K, Mann W, Nelson R, et al.
2009 · DOI: 10.1124/jpet.108.149211 · PMID: 19289567
Read on PubMed ↗International Journal of Colorectal Disease
Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients
Beck DE, Sweeney WB, McCarter MD, et al.
2014 · DOI: 10.1007/s00384-014-2030-8 · PMID: 25331030
Read on PubMed ↗11 peer-reviewed references listed. Citations verified against NCBI PubMed records. For research and educational reference only — does not constitute medical advice.
Researcher FAQ
No. Aero Peptides materials are sold exclusively for in-vitro research and laboratory analytical use. They are not intended to diagnose, treat, cure, or prevent any disease, and are not approved for human or animal administration.
By placing an order, you confirm that you are a qualified researcher and that the material will be used in accordance with all applicable institutional and jurisdictional regulations.
Each lot is independently tested for identity, purity, and mass using HPLC and mass spectrometry. The COA lists the lot number, test date, assay results, and the laboratory that performed the analysis.
Public COA documents are being prepared. In the meantime, you can request a COA for your specific lot and we’ll email it within 1 business day.
Orders ship quickly after your order is placed, from the US. Lyophilized peptides are shipped with insulation appropriate to season; short-term ambient excursions during transit do not measurably affect potency.
On receipt, store at −20°C in the sealed vial until reconstitution. See the handling matrix for full storage parameters. Tracked shipping is included; we ship to all US states and most international destinations.
Most peptides are reconstituted with bacteriostatic water (BAC). The volume depends on the target working concentration. Use our Peptide Calculator to compute volume, U-100 insulin syringe units, and doses per vial from peptide mass and target dose.
Once reconstituted, store at 2–8°C and use within 30 days. Protect the vial from light during storage and handling.
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⚠ Important research notice
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.